Hepatomegaly in transgenic mice expressing the homeobox geneCux-1

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin.

Inappropriate activation of the Wnt/beta-catenin signaling, resulting mainly from activating mutations of the beta-catenin gene, has been implicated recently in the development of hepatocellular carcinoma (HCC). We have generated transgenic mice expressing an oncogenic form of beta-catenin in their hepatocytes to analyze the effect of deregulated beta-catenin signaling on liver homeostasis. The...

Eosinophilia in Transgenic Mice Expressing

Experiments in vitro suggest that although interleukin 5 (IL5) stimulates the late stages ofeosinophil differentiation, other cytokines are required for the generation of eosinophil progenitor cells . In this study transgenic mice constitutively expressing the IL-5 gene were established using a genomic fragment of the 11,5 gene coupled to the dominant control region from the gene encoding human...

Transgenic Mice Expressing Different Levels

Eosinophilia in transgenic mice expressing interleukin 5

Experiments in vitro suggest that although interleukin 5 (IL-5) stimulates the late stages of eosinophil differentiation, other cytokines are required for the generation of eosinophil progenitor cells. In this study transgenic mice constitutively expressing the IL-5 gene were established using a genomic fragment of the IL-5 gene coupled to the dominant control region from the gene encoding huma...

Reduced susceptibility to IL-1 and endotoxin in transgenic mice expressing IL-1 in their lens.

To learn about the effects of chronic exposure to IL-1 we generated a transgenic (Tg) mouse line that expresses human IL-1 beta under the control of the lens alpha-A crystallin promoter. Expression of human IL-1 beta was restricted to the eye; neither the protein nor its mRNA were detected in various other organs of the Tg mice. The Tg mice develop severe ocular inflammation shortly after birth...